Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.

Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA, Chow CW. J Allergy Clin Immunol. 2013 Feb;131(2):512-20.e1-10. doi: 10.1016/j.jaci.2012.07.039. Epub 2012 Sep 13. ABSTRACT: BACKGROUND: Asthma is a chronic inflammatory disease characterized by airways hype

Skin and respiratory symptoms among workers with suspected work-related disease.

Arrandale VH, Kudla I, Kraut AG, Scott JA, Tarlo SM, Redlich CA, Holness DL. Occup Med (Lond). 2012 Sep;62(6):420-6. doi: 10.1093/occmed/kqs133. ABSTRACT: BACKGROUND: Many workers are exposed to chemicals that can cause both respiratory and skin responses. Although there has been much work on

Comparative cardiopulmonary effects of size-fractionated airborne particulate matter.

Amatullah H, North ML, Akhtar US, Rastogi N, Urch B, Silverman FS, Chow CW, Evans GJ, Scott JA. Inhal Toxicol. 2012 Feb;24(3):161-71. doi: 10.3109/08958378.2011.650235. Epub 2012 Feb 23. ABSTRACT: CONTEXT: Strong epidemiological evidence exists linking particulate matter (PM) exposures with

Asymmetric dimethylarginine is increased in asthma.

Scott JA, North ML, Rafii M, Huang H, Pencharz P, Subbarao P, Belik J, Grasemann H. Am J Respir Crit Care Med. 2011 Oct 1;184(7):779-85. doi: 10.1164/rccm.201011-1810OC. ABSTRACT:  RATIONALE: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that co

Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis.

Grasemann H, Al-Saleh S, Scott JA, Shehnaz D, Mehl A, Amin R, Rafii M, Pencharz P, Belik J, Ratjen F. Am J Respir Crit Care Med. 2011 May 15;183(10):1363-8. Epub 2011 Jan 28. ABSTRACT: RATIONALE: Airway nitric oxide is reduced in cystic fibrosis airways. Asymmetric dimethylarginine is an

Mortality in Vermont granite workers and its association with silica exposure.

Vacek PM, Verma DK, Graham WG, Callas PW, Gibbs GW. Occup Environ Med. 2011 May;68(5):312-8. Epub 2010 Sep 19. ABSTRACT: OBJECTIVES: To assess mortality in Vermont granite workers and examine relationships between silica exposure and mortality from lung cancer, kidney cancer, non-malignan

Factors associated with severe versus mild immunotherapy-related systemic reactions: a case-referent study.

Liss GM, Murphy-Berendts K, Epstein T, Bernstein DI. J Allergy Clin Immunol. 2011 May;127(5):1298-300. Epub 2011 Feb 18. PubMed link to article

Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.

North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, Scott JA. Respir Res. 2011 Feb 3;12:19. ABSTRACT: BACKGROUND: Arginase overexpression contributes to airways hyperresponsiveness (AHR) in asthma. Arginase expression is further augmented in cigarette smoking asthmatics, sugg

The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers.

Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E,Floras J, Nanthakumar K. J Am Coll Cardiol. 2011 Jan 11;57(2):198-206. ABSTRACT: OBJECTIVES: We tested the hypothesis that exposure to concentrated ambient par

Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles.

Akhtar US, McWhinney RD, Rastogi N, Abbatt JP, Evans GJ, Scott JA. Inhal Toxicol. 2010 Dec;22 Suppl 2:37-47. ABSTRACT: The composition of airborne particulate matter (PM) varies widely depending on its source, and recent studies have suggested that particle-associated adverse health effects are