Occupational Lung Disease

Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.

North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, Scott JA. Respir Res. 2011 Feb 3;12:19. ABSTRACT: BACKGROUND: Arginase overexpression contributes to airways hyperresponsiveness (AHR) in asthma. Arginase expression is further augmented in cigarette smoking asthmatics, sugg

The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers.

Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E,Floras J, Nanthakumar K. J Am Coll Cardiol. 2011 Jan 11;57(2):198-206. ABSTRACT: OBJECTIVES: We tested the hypothesis that exposure to concentrated ambient par

Jack Pepys Work-related Asthma Workshop, May 14, 2010

The 4th Jack Pepys Work-related Asthma Workshop on Work-related asthma and airway diseases, co-chaired by Dr Susan M Tarlo, University of Toronto and Dr Jean-Luc Malo, Université  de Montréal, was held 14th May 2010 at the University of Toronto at the Munk International Centre. Co-sponsors were t

Lung-Skin Workshop, November 4-5, 2005

Many allergens in the workplace continue to cause both occupational allergic contact dermatitis (OACD) and occupational allergic asthma (OAA).  Often, the same chemical may cause OAA in one worker and OACD in another.  In order to prevent occupational allergic skin or lung disease we need to under

Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles.

Akhtar US, McWhinney RD, Rastogi N, Abbatt JP, Evans GJ, Scott JA. Inhal Toxicol. 2010 Dec;22 Suppl 2:37-47. ABSTRACT: The composition of airborne particulate matter (PM) varies widely depending on its source, and recent studies have suggested that particle-associated adverse health effects are

Irritant-induced asthma. Pulmonary and Critical Care Sleep Update (PCCSU).

Tarlo SM. PCCSU Article. 15 November 2010. Link to article

Work-associated irritable larynx syndrome.

Hoy RF, Ribeiro M, Anderson J, Tarlo SM. Occup Med (Lond). 2010 Oct;60(7):546-51. ABSTRACT: BACKGROUND: Work-associated respiratory symptoms may be caused by disorders of both the lower and upper respiratory tract. We propose that occupational exposures may initiate and/or trigger recurrent hyp

Occupational health and safety issues in Ontario sawmills and veneer/plywood plants: a pilot study.

Verma DK, Demers C, Shaw D, Verma P, Kurtz L, Finkelstein M, des Tombe K, Welton T. J Environ Public Health. 2010;2010:526487. Epub 2011 Jan 3. ABSTRACT: A pilot study was conducted within the Ontario sawmill and veneer/plywood manufacturing industry. Information was collected by postal ques

Work-related asthma in health care in Ontario.

Liss GM, Buyantseva L, Luce CE, Ribeiro M, Manno M, Tarlo SM. Am J Ind Med. 2011 Apr;54(4):278-84. doi: 10.1002/ajim.20935. Epub 2011 Feb 15. ABSTRACT: BACKGROUND: The health of workers in health care has been neglected in the past. There are few reports regarding occupational asthma (

Prevention of occupational asthma.

Tarlo SM, Liss GM. Current Allergy and Asthma Reports 2010; 10:278-286. ABSTRACT: Prevention of occupational asthma related to a work-sensitizing agent ideally would be achieved by avoidance of exposures that cause immunologic sensitization and subsequent asthma. There are a few examples in whic