|Title||Key exposures and industries causing work-related contact dermatitis|
|Year||2006 – 2008|
|Investigators||Victoria Arrandale, Gary Liss, Linn Holness, Susan Tarlo, Melanie Pratt Denis Sasseville, Irena Kudla|
|CREOD Research Program||Occupational Skin and Respiratory Disease|
|Research Theme||Prevention, Burden of disease, Identification of allergens|
|Product Type||Research Study|
|Background||Traditionally, research related to occupational allergic contact dermatitis (OACD) and occupational asthma (OA) has been done in organ system silos, and rarely focusing on the two together. There is evidence that some agents cause both irritant and allergic responses in both the skin and respiratory systems, but these agents are not well documented. Better understanding of the inter-relationships between inhalation and dermal routes of exposure and between respiratory and skin responses to workplace chemicals would be helpful in developing appropriate prevention strategies.|
|Study Focus (Research Question/Goals/
|We used the North American Contact Dermatitis Group (NACDG) database, which now includes occupational factors, to identify common occupational contact allergens. We then linked this information to the respiratory literature to identify whether these agents caused occupational asthma (OA). We also assessed the utility of the NACDG database itself, as a tool for research and surveillance.
We analyzed patch test data for 3676 patients seen at the two Canadian NACDG Centres between 2001 and 2006.
|Key Findings||17% of subjects had an overall work-related CD diagnosis. Of these overall work-related cases, 64% had an allergic diagnosis (OACD) and 34% had an irritant diagnosis.
Industries most commonly affected by OACD were aircrafts and parts, beauty shops, and hospitals. Workers at highest risk of OACD were:
The 10 most common occupational contact allergens for OACD and their association with OA are listed below.
Established association with OA:
Possible association with OA:
Not listed in the literature or reference docs as a cause of OA:
There is a general lack of consistency in how sensitizer (or equivalent) notations are assigned across organizations. For example, sensitizer notation in the TLV handbook does not distinguish between the respiratory, dermal, or conjunctival organ systems.
Over time, the NACDG database may be useful for identifying common or emerging occupational contact allergens.
|Implications for Health/Labour Policy and Practice||
|Publication & Presentation Information||Publications