CREOD

Occupational Lung Disease

CREOD Research Flash – June 2019

Work-related asthma (WRA) remains one of the most common occupational lung diseases, accounting for about 16 per cent of all adult-onset asthma. In some cases the onset is a new condition resulting from workplace exposures. In other cases, pre-existing asthma is worsened by these exposures. Cleaning


Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma.

Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA, Chow CW. J Allergy Clin Immunol. 2013 Feb;131(2):512-20.e1-10. doi: 10.1016/j.jaci.2012.07.039. Epub 2012 Sep 13. ABSTRACT: BACKGROUND: Asthma is a chronic inflammatory disease characterized by airways hype


Skin and respiratory symptoms among workers with suspected work-related disease.

Arrandale VH, Kudla I, Kraut AG, Scott JA, Tarlo SM, Redlich CA, Holness DL. Occup Med (Lond). 2012 Sep;62(6):420-6. doi: 10.1093/occmed/kqs133. ABSTRACT: BACKGROUND: Many workers are exposed to chemicals that can cause both respiratory and skin responses. Although there has been much work on


Comparative cardiopulmonary effects of size-fractionated airborne particulate matter.

Amatullah H, North ML, Akhtar US, Rastogi N, Urch B, Silverman FS, Chow CW, Evans GJ, Scott JA. Inhal Toxicol. 2012 Feb;24(3):161-71. doi: 10.3109/08958378.2011.650235. Epub 2012 Feb 23. ABSTRACT: CONTEXT: Strong epidemiological evidence exists linking particulate matter (PM) exposures with


Dr. Gary Liss: Asthma in construction

St. Michael’s Hospital Occupational Medicine Rounds. 8:00 AM St. Michael’s Hospital, 30 Bond Street, Cardinal Carter Wing, Room 6-002. Webcasting: http://webcast.otn.ca/liveevents.html. For more information, contact Theresa Hollosi at HollosiT@smh.ca.


Dr. M. D. Lougheed: AllerGen funded WRA project

St. Michael’s Hospital Occupational Medicine Rounds. 8:00 AM St. Michael’s Hospital, 30 Bond Street, Cardinal Carter Wing, Room 6-002. Webcasting: http://webcast.otn.ca/liveevents.html. For more information, contact Theresa Hollosi at HollosiT@smh.ca.


Asymmetric dimethylarginine is increased in asthma.

Scott JA, North ML, Rafii M, Huang H, Pencharz P, Subbarao P, Belik J, Grasemann H. Am J Respir Crit Care Med. 2011 Oct 1;184(7):779-85. doi: 10.1164/rccm.201011-1810OC. ABSTRACT:  RATIONALE: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that co


Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with cystic fibrosis.

Grasemann H, Al-Saleh S, Scott JA, Shehnaz D, Mehl A, Amin R, Rafii M, Pencharz P, Belik J, Ratjen F. Am J Respir Crit Care Med. 2011 May 15;183(10):1363-8. Epub 2011 Jan 28. ABSTRACT: RATIONALE: Airway nitric oxide is reduced in cystic fibrosis airways. Asymmetric dimethylarginine is an


Mortality in Vermont granite workers and its association with silica exposure.

Vacek PM, Verma DK, Graham WG, Callas PW, Gibbs GW. Occup Environ Med. 2011 May;68(5):312-8. Epub 2010 Sep 19. ABSTRACT: OBJECTIVES: To assess mortality in Vermont granite workers and examine relationships between silica exposure and mortality from lung cancer, kidney cancer, non-malignan


Factors associated with severe versus mild immunotherapy-related systemic reactions: a case-referent study.

Liss GM, Murphy-Berendts K, Epstein T, Bernstein DI. J Allergy Clin Immunol. 2011 May;127(5):1298-300. Epub 2011 Feb 18. PubMed link to article